rtg4510 mouse model  (Eli Lilly)

Journal: Alzheimer's & Dementia : Translational Research & Clinical Interventions

Article Title: Haloperidol inactivates AMPK and reduces tau phosphorylation in a tau mouse model of Alzheimer's disease

doi: 10.1016/j.trci.2016.05.003

Figure Lengend Snippet: Total tau quantified in the cortex, striatum, and hippocampus with DA31 monoclonal antibody in rTg4510 mice treated for 6 weeks with haloperidol (N = 20) or sesame oil vehicle (N = 19). Levels of total tau did not differ significantly between groups.

Article Snippet: The rTg4510 mouse model manifests an aggressive phenotype of tau pathology in the forebrain structures in the form of neurofibrillary tangles with concomitant neuronal loss and cognitive deficits . rTg4510 breeding pairs (Tg(tetO-MAPT*P301L), stock #015815 and Tg(Camk2a-tT stock #003010)) were procured from Jackson Laboratories and housed in the Center for Comparative physiology at the Feinstein Institute for Medical Research where all the experiments described in this report were conducted.

Techniques:

Journal: Alzheimer's & Dementia : Translational Research & Clinical Interventions

Article Title: Haloperidol inactivates AMPK and reduces tau phosphorylation in a tau mouse model of Alzheimer's disease

doi: 10.1016/j.trci.2016.05.003

Figure Lengend Snippet: rTg4510 mice were treated with either haloperidol at a dose of 21 mg/kg/week or vehicle for 6 weeks

Article Snippet: The rTg4510 mouse model manifests an aggressive phenotype of tau pathology in the forebrain structures in the form of neurofibrillary tangles with concomitant neuronal loss and cognitive deficits . rTg4510 breeding pairs (Tg(tetO-MAPT*P301L), stock #015815 and Tg(Camk2a-tT stock #003010)) were procured from Jackson Laboratories and housed in the Center for Comparative physiology at the Feinstein Institute for Medical Research where all the experiments described in this report were conducted.

Techniques:

Journal: Alzheimer's & Dementia : Translational Research & Clinical Interventions

Article Title: Haloperidol inactivates AMPK and reduces tau phosphorylation in a tau mouse model of Alzheimer's disease

doi: 10.1016/j.trci.2016.05.003

Figure Lengend Snippet: rTg4510 mice were treated with either haloperidol at a dose of 21 mg/kg/week or vehicle for 2 weeks

Article Snippet: The rTg4510 mouse model manifests an aggressive phenotype of tau pathology in the forebrain structures in the form of neurofibrillary tangles with concomitant neuronal loss and cognitive deficits . rTg4510 breeding pairs (Tg(tetO-MAPT*P301L), stock #015815 and Tg(Camk2a-tT stock #003010)) were procured from Jackson Laboratories and housed in the Center for Comparative physiology at the Feinstein Institute for Medical Research where all the experiments described in this report were conducted.

Techniques: